Breathing pattern in patients with Parkinson’s disease
Identifieur interne : 000232 ( France/Analysis ); précédent : 000231; suivant : 000233Breathing pattern in patients with Parkinson’s disease
Auteurs : Laurent Vercueil [France] ; Jean Pierre Linard [France] ; Bernard Wuyam [France] ; Pierre Pollak [France] ; Gila Benchetrit [France]Source :
- Respiration Physiology [ 0034-5687 ] ; 1999.
English descriptors
- KwdEn :
Abstract
The improvement in motor performance resulting from levodopa administration in patients with Parkinson’s disease (PD) provides the opportunity to investigate ventilatory changes brought about by the disease. The aim of this study has been to investigate these changes in order to specify the mechanisms of the impairment in breathing in PD. Breathing patterns at rest were investigated in 11 patients with idiopathic PD both before (Off) and after (On) administration of levodopa at a dose improving their motor performance by at least 30%. Airflow (Fleisch head mounted on a mask), rib cage and abdomen movements (inductance plethysmography) were recorded in the Off condition 1 h after subjects woke up. Subjects then received levodopa and a new set of recordings was obtained 1 h later, in the On condition. Breath-by-breath processing of recordings was carried out and tidal volume (Vt), inspiratory (Ti) and expiratory (Te) durations were measured. The main finding was a lengthening of Ti resulting in a decrease in ventilation and in Vt/Ti, and an increase in Ti/Ttot in the On compared to the Off condition. In the On condition abnormal rib cage–abdomen plots patterns were found in four out of six subjects. A hypothesis on the effect of PD on breathing is proposed on grounds of normal diaphragmatic activity but impaired activity of the other respiratory muscles and more specifically the intercostal muscles.
Url:
DOI: 10.1016/S0034-5687(99)00075-4
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Main, to step Corpus: 001934
- to stream Main, to step Curation: 001686
- to stream Main, to step Exploration: 001E06
- to stream France, to step Extraction: 000232
Links to Exploration step
ISTEX:3B8F91B929A7A67AD577952D2FF038B3F7D2F7D7Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Breathing pattern in patients with Parkinson’s disease</title><author><name sortKey="Vercueil, Laurent" sort="Vercueil, Laurent" uniqKey="Vercueil L" first="Laurent" last="Vercueil">Laurent Vercueil</name></author><author><name sortKey="Linard, Jean Pierre" sort="Linard, Jean Pierre" uniqKey="Linard J" first="Jean Pierre" last="Linard">Jean Pierre Linard</name></author><author><name sortKey="Wuyam, Bernard" sort="Wuyam, Bernard" uniqKey="Wuyam B" first="Bernard" last="Wuyam">Bernard Wuyam</name></author><author><name sortKey="Pollak, Pierre" sort="Pollak, Pierre" uniqKey="Pollak P" first="Pierre" last="Pollak">Pierre Pollak</name><affiliation><country>France</country><placeName><settlement type="city">Grenoble</settlement><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region></placeName><orgName type="hospital" n="4">Centre hospitalier universitaire Grenoble Alpes</orgName></affiliation></author><author><name sortKey="Benchetrit, Gila" sort="Benchetrit, Gila" uniqKey="Benchetrit G" first="Gila" last="Benchetrit">Gila Benchetrit</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:3B8F91B929A7A67AD577952D2FF038B3F7D2F7D7</idno><date when="1999" year="1999">1999</date><idno type="doi">10.1016/S0034-5687(99)00075-4</idno><idno type="url">https://api.istex.fr/document/3B8F91B929A7A67AD577952D2FF038B3F7D2F7D7/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">001934</idno><idno type="wicri:Area/Main/Curation">001686</idno><idno type="wicri:Area/Main/Exploration">001E06</idno><idno type="wicri:Area/France/Extraction">000232</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Breathing pattern in patients with Parkinson’s disease</title><author><name sortKey="Vercueil, Laurent" sort="Vercueil, Laurent" uniqKey="Vercueil L" first="Laurent" last="Vercueil">Laurent Vercueil</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Clinique Neurologique, INSERM U-318, Centre Hospitalier Universitaire, 38 700 La Tronche</wicri:regionArea><wicri:noRegion>38 700 La Tronche</wicri:noRegion><wicri:noRegion>38 700 La Tronche</wicri:noRegion></affiliation></author><author><name sortKey="Linard, Jean Pierre" sort="Linard, Jean Pierre" uniqKey="Linard J" first="Jean Pierre" last="Linard">Jean Pierre Linard</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Physiologie Respiratoire Expérimentale, Théorique et Appliquée, Faculté de Médecine de Grenoble, 38 700 La Tronche</wicri:regionArea><wicri:noRegion>38 700 La Tronche</wicri:noRegion><wicri:noRegion>38 700 La Tronche</wicri:noRegion></affiliation></author><author><name sortKey="Wuyam, Bernard" sort="Wuyam, Bernard" uniqKey="Wuyam B" first="Bernard" last="Wuyam">Bernard Wuyam</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Physiologie Respiratoire Expérimentale, Théorique et Appliquée, Faculté de Médecine de Grenoble, 38 700 La Tronche</wicri:regionArea><wicri:noRegion>38 700 La Tronche</wicri:noRegion><wicri:noRegion>38 700 La Tronche</wicri:noRegion></affiliation></author><author><name sortKey="Pollak, Pierre" sort="Pollak, Pierre" uniqKey="Pollak P" first="Pierre" last="Pollak">Pierre Pollak</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Clinique Neurologique, INSERM U-318, Centre Hospitalier Universitaire, 38 700 La Tronche</wicri:regionArea><wicri:noRegion>38 700 La Tronche</wicri:noRegion><wicri:noRegion>38 700 La Tronche</wicri:noRegion><placeName><settlement type="city">Grenoble</settlement><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region></placeName><orgName type="hospital" n="4">Centre hospitalier universitaire Grenoble Alpes</orgName></affiliation></author><author><name sortKey="Benchetrit, Gila" sort="Benchetrit, Gila" uniqKey="Benchetrit G" first="Gila" last="Benchetrit">Gila Benchetrit</name><affiliation wicri:level="1"><country wicri:rule="url">France</country></affiliation><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Physiologie Respiratoire Expérimentale, Théorique et Appliquée, Faculté de Médecine de Grenoble, 38 700 La Tronche</wicri:regionArea><wicri:noRegion>38 700 La Tronche</wicri:noRegion><wicri:noRegion>38 700 La Tronche</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Respiration Physiology</title><title level="j" type="abbrev">RESP</title><idno type="ISSN">0034-5687</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1999">1999</date><biblScope unit="volume">118</biblScope><biblScope unit="issue">2–3</biblScope><biblScope unit="page" from="163">163</biblScope><biblScope unit="page" to="172">172</biblScope></imprint><idno type="ISSN">0034-5687</idno></series><idno type="istex">3B8F91B929A7A67AD577952D2FF038B3F7D2F7D7</idno><idno type="DOI">10.1016/S0034-5687(99)00075-4</idno><idno type="PII">S0034-5687(99)00075-4</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0034-5687</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Disease, Parkinson</term><term>Mammals, humans</term><term>Pattern of breathing, Parkinson’s disease</term><term>Pharmacological agents, levodopa</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The improvement in motor performance resulting from levodopa administration in patients with Parkinson’s disease (PD) provides the opportunity to investigate ventilatory changes brought about by the disease. The aim of this study has been to investigate these changes in order to specify the mechanisms of the impairment in breathing in PD. Breathing patterns at rest were investigated in 11 patients with idiopathic PD both before (Off) and after (On) administration of levodopa at a dose improving their motor performance by at least 30%. Airflow (Fleisch head mounted on a mask), rib cage and abdomen movements (inductance plethysmography) were recorded in the Off condition 1 h after subjects woke up. Subjects then received levodopa and a new set of recordings was obtained 1 h later, in the On condition. Breath-by-breath processing of recordings was carried out and tidal volume (Vt), inspiratory (Ti) and expiratory (Te) durations were measured. The main finding was a lengthening of Ti resulting in a decrease in ventilation and in Vt/Ti, and an increase in Ti/Ttot in the On compared to the Off condition. In the On condition abnormal rib cage–abdomen plots patterns were found in four out of six subjects. A hypothesis on the effect of PD on breathing is proposed on grounds of normal diaphragmatic activity but impaired activity of the other respiratory muscles and more specifically the intercostal muscles.</div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Auvergne-Rhône-Alpes</li><li>Rhône-Alpes</li></region><settlement><li>Grenoble</li></settlement><orgName><li>Centre hospitalier universitaire Grenoble Alpes</li></orgName></list><tree><country name="France"><noRegion><name sortKey="Vercueil, Laurent" sort="Vercueil, Laurent" uniqKey="Vercueil L" first="Laurent" last="Vercueil">Laurent Vercueil</name></noRegion><name sortKey="Benchetrit, Gila" sort="Benchetrit, Gila" uniqKey="Benchetrit G" first="Gila" last="Benchetrit">Gila Benchetrit</name><name sortKey="Benchetrit, Gila" sort="Benchetrit, Gila" uniqKey="Benchetrit G" first="Gila" last="Benchetrit">Gila Benchetrit</name><name sortKey="Linard, Jean Pierre" sort="Linard, Jean Pierre" uniqKey="Linard J" first="Jean Pierre" last="Linard">Jean Pierre Linard</name><name sortKey="Pollak, Pierre" sort="Pollak, Pierre" uniqKey="Pollak P" first="Pierre" last="Pollak">Pierre Pollak</name><name sortKey="Wuyam, Bernard" sort="Wuyam, Bernard" uniqKey="Wuyam B" first="Bernard" last="Wuyam">Bernard Wuyam</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonV1/Data/France/Analysis
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000232 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/France/Analysis/biblio.hfd -nk 000232 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonV1
|flux= France
|étape= Analysis
|type= RBID
|clé= ISTEX:3B8F91B929A7A67AD577952D2FF038B3F7D2F7D7
|texte= Breathing pattern in patients with Parkinson’s disease
}}
| This area was generated with Dilib version V0.6.23. |  |